Challenges

How does CAGI work? CAGI experiment participants are provided genetic variants and make predictions about resulting phenotypes. Independent assessors evaluate the predictions against experimentally characterized phenotypes.  The experiment culminates in the CAGI Conference with publications in a special journal issue.

There have been six editions of CAGI experiments, held between 2010 and 2022. Before you review them, please make sure you see our Data Use Agreement and Anonymity Policy. The seventh round of CAGI is planned to take place over the Spring and Summer of 2025.

CAGI6 Challenges

General information: CAGI6 challenge website, 13 challenges released

Skip to individual challenges: (1) MTHFR, (2) HMBS, (3) Calmodulin, (4) Annotate all missense, (5) Rare Genomes Project, (6) Intellectual Disability panel, (7) STK11, (8) Polygenic Risk Scores, (9) Splicing VUS, (10) Sherloc clinical classification, (11) MAPK1, (12) MAPK3, (13) SickKids6.

Off-cycle lightening challenges: (1) ARSA 

CAGI5 Challenges

General information: CAGI5 challenge website, 14 challenges released

Skip to individual challenges: (1) CALM1, (2) Clotting disease (DVT or PE) exomes, (3) Regulation Saturation, (4) Frataxin, (5) Annotate all missense, (6) PCM1, (7) TPMT and PTEN, (8) CHEK2, (9) GAA, (10) MaPSy, (11) Intellectual Disability panel, (12) ENIGMA, (13) SickKids5, (14) Vex-seq.

CAGI4 Challenges

General information: CAGI4 challenge website, 11 challenges released

Skip to individual challenges: (1) Bipolar exomes, (2) Crohn's exomes, (3) eQTL causal SNPs, (4) Hopkins clinical panel, (5) NAGLU, (6) NPM-ALK, (7) PGP, (8) Pyruvate kinase, (9) SickKids clinical genomes, (10) SUMO ligase, (11) Warfarin exomes.

CAGI3 Challenges

General information: CAGI3 challenge website, 10 challenges released

Skip to individual challenges: (1) Crohn's disease, (2) BRCA, (3) Splicing, (4) MRN, (5) FCH, (6) HA, (7) riskSNPs, (8) MR-1, (9) p16, (10) PGP.

CAGI2 Challenges

General information: CAGI2 challenge website, 12 challenges released, 1 withdrawn

Skip to individual challenges: (1) Asthma twins, (2) Breast cancer PkG , (3) CBS (4) Crohn’s disease, (5) Mouse exomes, (6) MR-1, (7) p53, (8) PGP, (9) RAD50, (10) Nav1.5, (11) riskSNPs, (12) Splicing (withdrawn).

CAGI1 Challenges

General information: CAGI1 challenge website, 3 challenges released

Skip to individual challenges: (1) CBS, (2) CHEK2, (3) PGP.

Last updated: August 12, 2024