The overarching goal of the Critical Assessment of Genome Interpretation (CAGI) is to establish the state of the art in the field of interpreting genomic variation through periodic editions of the CAGI experiment and extensive dissemination of their outcomes. For predictors, establishing state of the art involves recognizing best prediction strategies, highlighting innovation and identifying bottlenecks that prevent the field from advancing. For the user community, this involves providing trustworthy information about the most appropriate methods for a particular research or clinical application, and the best way to use the methods.
Why genome interpretation? Genomic variation is responsible for numerous rare diseases, for propensity for many common traits and diseases including cancer, for drug response, and is a key characteristic of cancer evolution. Genomic data therefore hold the promise of revolutionizing our understanding and treatment of human disease.
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CAGI Videos, Presentations and Data
You must register and log in to gain access to CAGI videos, presentations and, in some cases, data.
CAGI7 Tracker ☀️
CAGI7 challenges
- Ongoing during summer and fall 2025. Twelve challenges announced, eight open for submission. ☀️
CAGI7 conference
- Planned for December 2025, in Boston, same venue as for CAGI⁕⁕. More details soon.
CAGI7 special issue
- To be announced.
CAGI6 Tracker
CAGI6 challenges
- Closed on December 31, 2021. Assessment completed. Presentation of results at CAGI6 conference.
CAGI6 conference
- May 14-16, 2022 at the Brower Center in Berkeley, CA 94704, USA. In person, with synchronous hybrid support.
- jointly between Human Genetics and Human Genomics.
CAGI Educational Activities
Our past activities are listed on the CAGI MLD Bootcamp page.
Recent Announcements
June 2, 2025 ☀️
- CAGI7 has started!
February 17, 2025
- CAGI7 challenges are in preparation for this year. More updates soon!
July 15, 2024
- The CAGI6 special issue now closed.
February 22, 2024
- The CAGI flagship paper published in Genome Biology.
January 31, 2024
- The CAGI6 special issue deadline extended to April 30, 2024.
Last updated: July 1, 2025