The overarching goal of the Critical Assessment of Genome Interpretation (CAGI) is to establish the state of the art in the field of interpreting genomic variation though periodic editions of the CAGI experiment and extensive dissemination of their outcomes. For predictors, establishing state of the art involves recognizing best prediction strategies, highlighting innovation and identifying bottlenecks that prevent the field from advancing. For the user community, this involves providing trustworthy information about the most appropriate methods for a particular research or clinical application, and the best way to use the methods.

Why genome interpretation? Genomic variation is responsible for numerous rare diseases, for propensity for many common traits and diseases including cancer, for drug response, and is a key characteristic of cancer evolution. Genomic data therefore hold the promise of revolutionizing our understanding and treatment of human disease.

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 ^☀️ CAGI6 tracker ^☀️

CAGI6 challenges 

• • Closed on December 31, 2021. Assessment completed. Presentation of results at CAGI6 conference.

CAGI6 conference

• • May 14-16, 2022 at the Brower Center in Berkeley, CA 94704, USA. In person, with synchronous hybrid support.

CAGI6 journal special issue

• • Planned to start after the CAGI6 conference and to appear in Human Mutation. More soon ☀️

 ^☀️ CAGI at ASHG 2022 ^☀️

We will be hosting an invited session, titled “New advances in computational genome interpretation: from prediction to the clinic” at ASHG 2022. Speakers: Vikas Pejaver (Mount Sinai), Sarah Stenton (Broad Institute), Sung Chun (Boston Children’s), and Malia Fullerton (University of Washington). Join us in Los Angeles, California, USA, October 25-29, 2022.

Recent Announcements

May 16, 2022

• • CAGI6 conference ends. ☀️

March 11, 2022

• • CAGI6 conference announced.

December 31, 2021

• • All CAGI6 challenges are now closed. Assessment in progress.

December 1, 2021

• • All challenges, except for SickKids6 are now closed.

Last update: May 29, 2022