The overarching goal of the Critical Assessment of Genome Interpretation (CAGI) is to establish the state of the art in the field of interpreting genomic variation though periodic editions of the CAGI experiment and extensive dissemination of their outcomes. For predictors, establishing state of the art involves recognizing best prediction strategies, highlighting innovation and identifying bottlenecks that prevent the field from advancing. For the user community, this involves providing trustworthy information about the most appropriate methods for a particular research or clinical application, and the best way to use the methods.
Why genome interpretation? Genomic variation is responsible for numerous rare diseases, for propensity for many common traits and diseases including cancer, for drug response, and is a key characteristic of cancer evolution. Genomic data therefore hold the promise of revolutionizing our understanding and treatment of human disease.
Follow us on Twitter @CAGInews
☀️ CAGI6 tracker ☀️
CAGI6 challenges
- • Closed on December 31, 2021
CAGI6 conference
- • tentatively planned for March, 2022, as a virtual event
CAGI6 journal special issue
- • planned to start after the CAGI6 conference and to be appear in Human Mutation
Recent Announcements
December 31, 2021
- • All CAGI6 challenges are now closed. Assessment in progress.
December 1, 2021
- • All challenges, except for SickKids6 are now closed.
November 15, 2021
- • The deadline for the SickKids6 challenge extended to December 31, 2021 This is a hard deadline.
October 12, 2021
- • Multiple challenges close, CAGI conference planned for February 2022.
September 1, 2021
- • The STK11 challenge closes.
August 14, 2021
- • Submission deadlines extended for several challenges.
August 4, 2021
- • MAPK3 challenge starts, similar to MAPK1. SickKids6 challenge announced. Find molecular events underlying disease in clinical genomes and exomes.
July 8, 2021
- • Two new challenges released. MAPK1 and Sherloc clinical classification.
June 15, 2021
- • MTHFR challenge extended till June 24. All other challenges closing in August or later.
June 8, 2021
- • A total of nine challenges are now open. See CAGI6 webpage.
June 1, 2021
- • Two more challenges open (HMBS, Annotate All Missense, in addition to MTHFR)
May 20, 2021
- • Three new challenges announced for CAGI6. See CAGI6 webpage.
May 3, 2021
- • CAGI6 is starting! Five challenges announced. See CAGI6 webpage.
January 4, 2021
- • We are actively recruiting challenges for Summer 2021.
December 15, 2020
- • We are hiring a web framework and content manager developer. Please contact us if you are interested in this position. Position filled in May 2021.
November 23, 2020
- • CAGI 6 challenge planned for Summer 2021.
June 3, 2020
- • CAGI grant awarded by the NIH.
Last update: January 1, 2022