Welcome to the CAGI experiment!

CAGI prediction season is now open

The Fourth Critical Assessment of Genome Interpretation (CAGI) prediction season has opened. On 3 August 2015 we released the first three challenges. Additional challenges will roll out soon. A preview of the challenges under consideration and development is available in the recent newsletter.

Please distribute this information widely and follow our Twitter feed @CAGInews and the web site for updates. For more information on the CAGI experiment, see the Overview.

The challenge season will extend through early December, with the first challenges closing beginning in mid-November. The CAGI meeting will occur around March 2016.

Challenges released:

  • Crohn's exomes (released 3 August 2015):
    Distinguish between exomes of Crohn's disease patients and healthy individuals
  • NAGLU (released 3 August 2015):
    Predict the effect of naturally occurring missense mutations on cellular enzymatic activity
  • NPM-ALK (released 3 August 2015):
    The Nucleophosmin - Anaplastic Lymphoma Kinase fusion protein (NPM-ALK): predict the effect of mutations in the kinase domain on kinase activity and Hsp90 binding affinity
  • Warfarin exomes (released 6 August 2015):
    Estimate patients’ therapeutic warfarin doses from their exome sequence
  • SUMO ligase (released 4 September 2015):
    Human SUMO ligase (UBE2l): predict the effects of missense mutations on competitive growth in a high-throughput yeast complementation assay
  • eQTL causal SNPs (released 4 September 2015):
    Identify regulatory sequences and eQTL-causal variants, and estimate their effects on activation of transcription in a massively parallel reporter assay
  • PGP (released 4 September 2015):
    The Personal genome project (PGP): predict individuals' phenotypes