CAGI* Workshop:
Assessing the future of genome interpretation

Start: 6 December 2019, 1pm
End: 8 December 2019, 12 pm (with an optional breakout session in the later p.m.)
Location: UCSF Mission Bay, San Francisco, California, USA

*** Registration is now open ***

Registration fees*:

Type Trainee** Academic Industry Sponsor
Regular $450 $750 $1,050 $1,750
Late $500 $800 $1,100
Onsite $550 $850 $1,150
* A 10% discount is available to all ISCB members.
** Trainees accepted for a fellowship should register using the full (non-discounted) Academic rate.

Deadline for regular registration: 19 November 2019

Please register. While registering, you will be asked to answer our brief demographics questionnaire. This information is required for us to maintain NIH funding. Thank you for your understanding.

Confirmed speakers
Michael Snyder, Shamil Sunyaev, Serafim Batzoglou, John Moult, Predrag Radivojac, Iddo Friedberg, Melissa Cline, Sean Mooney, Steven Mount, Anne O'Donnell-Luria, Malia Fullerton, Barbara Koenig, Olivier Lichtarge, Nilah Ioannidis

The agenda has now been finalized. Please refer to this for information on dates, locations and sessions.

Call for abstracts (deadline for receipt: 12 November 2019)
Please follow our guidelines for submitting an abstract. Please submit your abstract to

Please note, that the 12 November 2019 deadline only applies to abstracts not associated with a fellowship application. For fellowship applicants, please submit an abstract along with your fellowship application by 5 November 2019.

Fellowship applications (deadline for receipt now extended to: 5 November 2019)
Fellowships are available, and in previous years we were able to provide support to most eligible applicants. To be eligible for fellowship support, you must be a student, postdoc or other non-faculty scientist working in the US, or a US citizen or permanent resident working outside the US. We may also be able to support some members of under-represented groups, including those with disabilities, regardless of citizenship. All eligible applicants are strongly encouraged to apply for a fellowship and are likely to receive one.

Please download the fellowship application form and submit the completed application to The deadline for both abstract and fellowship submission for fellowship applicants is 5 November 2019.

Call for sponsors
If you belong to an organization that would like to support the CAGI conference via sponsorship, please contact us at

Description of the CAGI* meeting
The CAGI* meeting takes a holistic perspective, as compared with previous CAGI meetings that focused on the results of specific challenges. This meeting will reflect on the accomplishments of the five editions of CAGI and seek to shape our vision for the future. This is a once in a decade opportunity to take a fresh look at what CAGI is about and where it should go next.

We will be organizing sessions of talks by variant type (missense, expression, splicing), and by disease type (complex type, cancer, and rare disease), as well as talks on new methodologies, such as AI, and the impact of new databases. We aim to engage wider participation beyond the CAGI community. Pending sufficient interest, we will additionally be hosting salons of maverick ideas prior to the meeting.

In these talks and follow-up discussions, we will be looking to address questions such as, what is the current state of pathogenicity prediction tools? What sorts of data will be available in the future, and how can they be incorporated in the study of germline genetic variation? What are some advanced evaluation strategies for assessing the performance of prediction tools? How can we move towards more reliable ACMG guidelines?

We look forward to welcoming all participants and anticipate many stimulating debates and fruitful discussions on the future of genome interpretation and CAGI.

Information on accommodation, parking and other logistics.

Funding for this workshop was made possible (in part) by R13 HG006650 from the National Human Genome Research Institute. CAGI has also been supported by U41 HG007346 from the NHGRI.

The 2019 Human Mutation CAGI Special Issue is now out

The 2019 CAGI Special issue in Human Mutation has now been published. 36 papers are included in this issue, available through free access and more are being accepted in the online collection.

We would like to thank all CAGI participants for your extraordinary contributions at all levels and look forward to your engagement in further advancing variant interpretation.

CAGI HuMu 2019