CAGI 4 challenges and timeline

Dear CAGI participant,

Based on CAGI participants' feedback, the fourth CAGI experiment will run from August 2015 to March 2016 as follows:

Prediction season: August to November 2015, with about 3 months per challenge. We are rolling out further challenges now. A specific close date will be posted for each challenge.

Assessment season: December 2015 to February 2016.

Conference: tentatively scheduled for two days among 18-20 or 25-27 March 2016 in the San Francisco Bay Area.

CAGI 4 launched on 3 August 2015, with four challenges released thus far, below. More challenges will be released over the next 2 to 3 weeks. See Developing challenges, https://genomeinterpretation.org/content/developing-challenges-4.

Challenges released so far:
* Crohn's exomes: Distinguish between exomes of Crohn's disease patients and healthy individuals
* NAGLU: N-acetyl-glucosaminidase: predict the effect of naturally occurring missense mutations on cellular enzyme activity
* NPM-ALK: Anaplastic Lymphoma Kinase: predict the effect of mutations in the kinase domain of the NPM-ALK fusion gene on kinase activity and Hsp90 binding affinity
* Warfarin exomes: Estimate patients' therapeutic warfarin doses from their exome sequences

Additional challenges cover:
* Protein-Coding Variants
* Splicing Variants
* Regulatory Variants
* Clinical Sequences
* Research Exomes: predict phenotypes and mutations

Please distribute widely and follow our Twitter feed @CAGInews and the web site for updates.