The first round of CAGI was organized in the fall 2010. We want to express our appreciation to everyone who participated in CAGI and RiskSNPs 2010. This initial experiment was a great success with over 100 prediction submissions from 8 countries. The workshop on 10 December 2010 gathered an enthusiastic international group of 40 people at Berkeley. A summary of the CAGI 2010 Conference proceedings has been published in Nature News.