All challenges have now closed for submissions. The deadline for most prediction submissions for the CAGI 2012-13 challenges was 25 April 2013 at 11:59 pm PDT.
- Crohn's disease: Distinguish between exomes of Crohn's disease patients and healthy individuals. Exomes of Crohn's disease patients and healthy individuals (provided by Andre Franke). Challenge: predict which individuals have Crohn's.
- Variants in DNA double-strand break repair genes (provided by Sean Tavtigian). Challenge: predict probability of each variant occurring in a breast cancer case versus healthy control.
- Variants of BRCA1 and BRCA2 (provided by Robert Nussbaum). Challenge: predict which variants are associated with increased risk for breast cancer.
- Mutations in p53 gene exons affecting mRNA splicing (provided by Jeremy Sanford). Challenge: predict how variants impact splicing.
- New PGP genomes (provided by George Church). Challenge: Predict clinical phenotypes from genome data, and match individuals to their health records.
- Exomes from a family with familial combined hyperlipidemia and a family with hypoalphalipoproteinemia, lipid metabolism disorders (provided by John Kane and Pui-Yan Kwok). Challenges: identify stricken individuals, a causative variant for elevated LDL-C, and optionally predict lipid profiles of individuals.
- Variants of a p16 tumor suppressor protein (provided by Silvio Tosatto). Challenge: predict how well variants inhibit cell proliferation.
- Shewanella oneidensis MR-1 gene disruptions (provided by Adam Arkin). Challenge: Predict impact of microbial gene disruptions on cell growth under stress conditions
- riskSNPs disease-associated loci (provided by John Moult). Challenge: identify potential causative SNPs.
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