AA_substitution(s)
D3A
L5A
T6A
E7A
E8A
Q9A
I10A
E12A
F13A
K14A
E15A
S18A
D21A
K22A
D23A
G24A
D25A
G26A
T27A
I28A
T29A
T30A
K31A
E32A
L33A
T35A
V36A
M37A
R38A
S39A
L40A
G41A
P44A
T45A
E46A
E48A
L49A
D51A
I53A
N54A
E55A
V56A
D57A
D59A
N61A
G62A
T63A
I64A
D65A
F66A
P67A
E68A
L70A
T71A
M73A
R75A
K76A
M77A
K78A
D79A
T80A
D81A
S82A
E83A
E84A
E85A
I86A
E88A
V92A
D94A
D96A
G97A
G99A
Y100A
I101A
E105A
H108A
V109A
M110A
T111A
L113A
G114A
E115A
L117A
T118A
D119A
E120A
E121A
V122A
D123A
E124A
M125A
I126A
E128A
D130A
I131A
D132A
G133A
D134A
G135A
V137A
N138A
E140A
E141A
V143A
M145A
M146A
T147A
A2V
D3V
L5V
T6V
E7V
E8V
Q9V
I10V
A11V
E12V
F13V
E15V
A16V
F17V
S18V
L19V
F20V
D21V
K22V
D23V
G24V
D25V
G26V
T27V
I28V
T29V
E32V
L33V
G34V
T35V
M37V
R38V
L40V
G41V
Q42V
P44V
T45V
E46V
A47V
E48V
L49V
D51V
M52V
I53V
N54V
E55V
D57V
A58V
D59V
G60V
G62V
T63V
I64V
D65V
F66V
P67V
E68V
F69V
L70V
T71V
M72V
M73V
A74V
K76V
M77V
K78V
D79V
T80V
D81V
E83V
E84V
E85V
I86V
R87V
E88V
A89V
F90V
F93V
D94V
K95V
D96V
G97V
G99V
Y100V
I101V
S102V
A103V
A104V
E105V
R107V
M110V
T111V
L113V
G114V
E115V
K116V
L117V
T118V
D119V
E120V
E121V
D123V
E124V
M125V
I126V
R127V
E128V
A129V
D130V
I131V
D132V
G133V
D134V
G135V
Q136V
N138V
Y139V
E140V
E141V
Q144V
M145V
M146V
T147V
A148V
D3L
Q4L
E7L
Q9L
I10L
A11L
E12L
F13L
K14L
E15L
A16L
F17L
S18L
F20L
D21L
K22L
G24L
T27L
I28L
T29L
T30L
K31L
E32L
G34L
V36L
M37L
R38L
S39L
Q42L
P44L
T45L
E46L
A47L
E48L
Q50L
D51L
M52L
I53L
N54L
E55L
V56L
D57L
D59L
N61L
T63L
I64L
D65L
F66L
P67L
E68L
F69L
M72L
M73L
R75L
K76L
M77L
K78L
D79L
T80L
E83L
E84L
E85L
I86L
R87L
A89L
F90L
R91L
V92L
F93L
D94L
G99L
Y100L
I101L
S102L
A104L
R107L
H108L
M110L
T111L
G114L
E115L
K116L
T118L
D119L
E120L
E121L
V122L
D123L
E124L
M125L
I126L
R127L
E128L
A129L
D130L
I131L
D132L
G133L
Q136L
V137L
Y139L
E140L
F142L
V143L
Q144L
M145L
M146L
L5I
T6I
A11I
F13I
K14I
E15I
A16I
F17I
L19I
F20I
D21I
K22I
T27I
T29I
T30I
K31I
L33I
G34I
T35I
V36I
M37I
S39I
L40I
N43I
P44I
T45I
E46I
A47I
E48I
L49I
M52I
N54I
E55I
N61I
T63I
D65I
F66I
P67I
F69I
L70I
T71I
M72I
M73I
A74I
R75I
K76I
M77I
K78I
D79I
T80I
S82I
E83I
E84I
E85I
A89I
F90I
R91I
V92I
F93I
K95I
D96I
N98I
Y100I
S102I
A103I
A104I
L106I
H108I
V109I
M110I
T111I
N112I
L113I
E115I
K116I
L117I
T118I
E120I
E121I
V122I
D123I
E124I
M125I
R127I
A129I
D130I
Q136I
V137I
N138I
Y139I
E140I
E141I
F142I
V143I
M145I
M146I
T147I
K149I
L5M
T6M
I10M
A11M
F13M
K14M
E15M
A16M
K22M
T27M
I28M
T29M
T30M
K31M
E32M
L33M
T35M
V36M
R38M
L40M
E46M
A47M
E48M
L49M
I53M
N54M
E55M
V56M
N61M
G62M
T63M
I64M
D65M
F69M
L70M
T71M
R75M
K78M
T80M
E83M
E85M
K95M
N98M
S102M
A103M
V109M
T111M
L113M
E115M
K116M
L117M
T118M
E120M
V122M
I126M
R127M
I131M
G135M
Q136M
E140M
E141M
V143M
K149M
A2F
D3F
E7F
Q9F
I10F
A11F
K14F
A16F
S18F
D21F
K22F
T27F
I28F
T29F
K31F
L33F
T35F
V36F
L40F
N43F
T45F
E46F
A47F
E48F
L49F
M52F
I53F
N54F
E55F
D57F
A58F
D59F
N61F
T63F
I64F
D65F
P67F
E68F
L70F
T71F
M72F
M73F
K78F
D79F
T80F
E84F
E85F
I86F
R87F
E88F
V92F
D94F
G97F
N98F
G99F
Y100F
I101F
S102F
A103F
R107F
H108F
V109F
M110F
T111F
L113F
G114F
K116F
L117F
T118F
D119F
E120F
V122F
D123F
M125F
I126F
R127F
D130F
I131F
D132F
D134F
V137F
N138F
Y139F
E140F
E141F
T147F
A2Y
D3Y
E7Y
Q9Y
A11Y
F13Y
K14Y
E15Y
A16Y
F17Y
S18Y
F20Y
D21Y
K22Y
D23Y
G24Y
T27Y
K31Y
L33Y
T35Y
S39Y
L40Y
N43Y
E46Y
E48Y
L49Y
D51Y
N54Y
E55Y
D57Y
D59Y
G60Y
N61Y
I64Y
D65Y
F66Y
E68Y
F69Y
L70Y
T71Y
K76Y
K78Y
D79Y
T80Y
D81Y
E83Y
E84Y
E85Y
R87Y
F90Y
F93Y
D94Y
D96Y
N98Y
G99Y
A103Y
H108Y
N112Y
L113Y
G114Y
E115Y
K116Y
T118Y
D119Y
E120Y
E121Y
D123Y
E124Y
A129Y
D130Y
I131Y
D132Y
D134Y
N138Y
E140Y
E141Y
F142Y
Q144Y
A2W
L5W
Q9W
F13W
E15W
A16W
S18W
D21W
K22W
T27W
I28W
K31W
L33W
T35W
V36W
M37W
R38W
S39W
L40W
Q42W
N43W
T45W
E46W
A47W
E48W
L49W
Q50W
M52W
I53W
N54W
E55W
D57W
T63W
D65W
F66W
E68W
L70W
M72W
R75W
K76W
K78W
D79W
T80W
E83W
R87W
R91W
D94W
D96W
G97W
G99W
S102W
T111W
L113W
G114W
E115W
T118W
D119W
E120W
V122W
D123W
M125W
I126W
R127W
D130W
I131W
G133W
Q136W
V137W
Y139W
Q144W
D3R
Q4R
L5R
E7R
E8R
Q9R
I10R
A11R
E12R
F13R
K14R
E15R
A16R
F17R
S18R
L19R
D21R
K22R
D23R
G24R
G26R
T27R
I28R
T29R
T30R
K31R
L33R
G34R
T35R
V36R
M37R
S39R
L40R
G41R
Q42R
N43R
P44R
T45R
E46R
A47R
E48R
L49R
Q50R
D51R
M52R
I53R
N54R
E55R
V56R
D57R
G60R
N61R
G62R
T63R
I64R
D65R
F66R
P67R
E68R
F69R
L70R
T71R
M72R
M73R
A74R
K76R
M77R
K78R
D79R
T80R
S82R
E83R
E84R
E85R
I86R
E88R
F90R
D94R
K95R
G97R
G99R
Y100R
I101R
S102R
A103R
A104R
L106R
H108R
M110R
N112R
L113R
G114R
K116R
L117R
T118R
D119R
E121R
V122R
D123R
E124R
M125R
I126R
E128R
A129R
D130R
I131R
D132R
G133R
D134R
G135R
Q136R
N138R
Y139R
E140R
E141R
Q144R
M145R
M146R
K149R
D3H
Q4H
L5H
E7H
Q9H
E12H
K14H
E15H
A16H
F17H
F20H
D21H
K22H
D23H
D25H
T27H
K31H
E32H
L33H
R38H
L40H
G41H
Q42H
N43H
P44H
E46H
A47H
E48H
Q50H
D51H
N54H
E55H
D57H
D59H
N61H
G62H
D65H
F66H
P67H
A74H
K76H
K78H
D79H
E83H
E85H
R87H
E88H
F93H
D94H
K95H
D96H
N98H
Y100H
S102H
L106H
R107H
N112H
L113H
E115H
K116H
L117H
D119H
E120H
V122H
D123H
E128H
D130H
I131H
Q136H
N138H
Y139H
Q144H
D3K
Q4K
L5K
E7K
E8K
Q9K
I10K
E12K
E15K
A16K
D21K
D23K
T27K
I28K
T29K
T30K
E32K
G34K
M37K
R38K
S39K
L40K
Q42K
N43K
T45K
E46K
A47K
E48K
Q50K
M52K
I53K
N54K
E55K
V56K
D57K
N61K
T63K
D65K
P67K
E68K
L70K
T71K
M72K
M73K
R75K
M77K
D79K
T80K
S82K
E83K
E84K
E85K
R87K
E88K
G97K
N98K
A103K
A104K
E105K
L106K
M110K
T111K
N112K
L113K
G114K
E115K
T118K
D119K
E120K
E121K
V122K
D123K
E124K
R127K
E128K
A129K
D130K
I131K
G133K
D134K
G135K
N138K
Y139K
E140K
E141K
V143K
Q144K
M145K
M146K
A2D
L5D
E7D
E8D
Q9D
I10D
A11D
E12D
F13D
K14D
E15D
A16D
F20D
K22D
G24D
G26D
T27D
K31D
E32D
G34D
V36D
G41D
Q42D
N43D
T45D
E46D
A47D
E48D
I53D
N54D
E55D
A58D
G60D
N61D
G62D
T63D
F66D
E68D
L70D
T71D
A74D
K76D
K78D
T80D
S82D
E83D
E84D
E85D
E88D
A89D
V92D
K95D
G97D
N98D
G99D
Y100D
S102D
A103D
A104D
E105D
H108D
V109D
N112D
G114D
E115D
K116D
L117D
T118D
E120D
E121D
V122D
E124D
E128D
A129D
G133D
Q136D
V137D
N138D
Y139D
E140D
E141D
Q144D
A148D
A2E
D3E
L5E
Q9E
I10E
A11E
K14E
A16E
D21E
K22E
D23E
D25E
T27E
T30E
K31E
L33E
G34E
V36E
R38E
S39E
G41E
Q42E
T45E
A47E
L49E
Q50E
D51E
M52E
N54E
V56E
D57E
A58E
D59E
G62E
T63E
D65E
F66E
P67E
L70E
M72E
M73E
A74E
R75E
K76E
M77E
K78E
D79E
T80E
D81E
A89E
K95E
D96E
G97E
V109E
T111E
L113E
G114E
K116E
T118E
D119E
V122E
D123E
M125E
R127E
A129E
D130E
D132E
G133E
D134E
G135E
Q136E
V143E
Q144E
K149E
A2S
D3S
L5S
T6S
E8S
Q9S
I10S
A11S
F13S
K14S
E15S
A16S
F17S
L19S
F20S
D21S
K22S
D23S
G24S
G26S
T27S
I28S
T29S
T30S
K31S
L33S
G34S
T35S
V36S
M37S
R38S
L40S
G41S
N43S
P44S
T45S
E46S
A47S
E48S
L49S
D51S
M52S
I53S
N54S
E55S
D57S
A58S
D59S
G60S
N61S
G62S
T63S
I64S
D65S
F66S
P67S
F69S
L70S
T71S
M73S
A74S
R75S
K76S
M77S
K78S
D79S
T80S
D81S
E85S
I86S
R87S
A89S
F90S
F93S
D94S
K95S
D96S
G97S
N98S
G99S
Y100S
I101S
A103S
A104S
E105S
L106S
R107S
H108S
M110S
T111S
N112S
L113S
E115S
K116S
L117S
T118S
D119S
E120S
E121S
V122S
D123S
E124S
M125S
I126S
R127S
A129S
D130S
I131S
D132S
G133S
D134S
G135S
Q136S
N138S
Y139S
F142S
V143S
Q144S
M145S
T147S
A148S
A2T
D3T
L5T
Q9T
I10T
A11T
E12T
K14T
E15T
A16T
S18T
F20T
D21T
K22T
D23T
I28T
K31T
L33T
V36T
M37T
R38T
S39T
L40T
N43T
P44T
A47T
E48T
D51T
M52T
I53T
N54T
V56T
D57T
A58T
N61T
G62T
I64T
D65T
F66T
P67T
E68T
F69T
L70T
M72T
M73T
A74T
R75T
K76T
M77T
K78T
D79T
S82T
E83T
E85T
I86T
R87T
A89T
K95T
N98T
G99T
Y100T
I101T
S102T
A103T
A104T
L106T
V109T
M110T
N112T
G114T
E115T
K116T
D119T
V122T
E124T
M125T
I126T
R127T
A129T
I131T
Q136T
N138T
E140T
V143T
Q144T
M145T
M146T
A148T
K149T
A2N
D3N
L5N
Q9N
I10N
A11N
E12N
K14N
E15N
A16N
F20N
D21N
K22N
D23N
G24N
D25N
G26N
T27N
I28N
T30N
K31N
T35N
V36N
M37N
R38N
S39N
L40N
G41N
T45N
E46N
A47N
E48N
Q50N
D51N
M52N
E55N
D57N
D59N
G60N
G62N
T63N
I64N
D65N
F66N
E68N
L70N
T71N
M72N
M73N
A74N
R75N
K76N
K78N
D79N
T80N
D81N
S82N
E83N
E84N
E85N
I86N
R87N
D94N
K95N
D96N
G97N
G99N
Y100N
S102N
A103N
H108N
L113N
E115N
K116N
L117N
T118N
D119N
E120N
E121N
D123N
E124N
I126N
R127N
D130N
I131N
D132N
G133N
D134N
Y139N
E140N
Q144N
T147N
K149N
D3Q
L5Q
E7Q
E12Q
F13Q
K14Q
E15Q
A16Q
L19Q
F20Q
D21Q
K22Q
I28Q
K31Q
L33Q
R38Q
L40Q
G41Q
P44Q
E46Q
A47Q
E48Q
L49Q
N54Q
E55Q
D57Q
G62Q
T63Q
D65Q
F66Q
P67Q
E68Q
L70Q
M72Q
A74Q
K76Q
M77Q
K78Q
D79Q
E83Q
E84Q
E85Q
R87Q
E88Q
R91Q
K95Q
G99Q
Y100Q
L106Q
R107Q
H108Q
L113Q
G114Q
E115Q
K116Q
L117Q
E121Q
V122Q
M125Q
I126Q
D130Q
I131Q
D134Q
G135Q
Y139Q
E140Q
M145Q
K149Q
A2G
D3G
L5G
E7G
E8G
Q9G
I10G
A11G
E12G
F13G
E15G
A16G
D21G
K22G
D23G
D25G
T27G
I28G
T29G
T30G
K31G
E32G
L33G
V36G
R38G
S39G
Q42G
N43G
T45G
E46G
A47G
E48G
L49G
Q50G
D51G
M52G
I53G
N54G
E55G
V56G
D57G
A58G
D59G
T63G
D65G
F66G
E68G
F69G
L70G
T71G
M72G
A74G
R75G
K76G
M77G
K78G
D79G
T80G
D81G
S82G
E83G
E84G
E85G
I86G
R87G
E88G
R91G
V92G
D94G
K95G
D96G
N98G
S102G
A103G
A104G
E105G
R107G
V109G
M110G
T111G
N112G
L113G
E115G
K116G
L117G
T118G
D119G
E120G
E121G
V122G
D123G
E124G
M125G
I126G
R127G
E128G
A129G
D130G
I131G
D132G
D134G
V137G
N138G
Y139G
E140G
E141G
V143G
Q144G
A148G
Q9C
A11C
F13C
E15C
A16C
F17C
S18C
F20C
D21C
K22C
G24C
G26C
T27C
T30C
K31C
G34C
T35C
V36C
R38C
S39C
G41C
E46C
A47C
E48C
L49C
I53C
N54C
E55C
D57C
D59C
G60C
G62C
T63C
D65C
F66C
E68C
F69C
L70C
R75C
K76C
K78C
D79C
T80C
D81C
S82C
E85C
R87C
A89C
F90C
R91C
F93C
D94C
G97C
G99C
Y100C
I101C
S102C
A103C
R107C
H108C
T111C
L113C
G114C
L117C
D119C
E120C
E121C
D123C
I126C
R127C
D130C
I131C
G133C
D134C
G135C
V137C
N138C
Y139C
F142C
Q144C
A2P
D3P
Q4P
L5P
T6P
Q9P
I10P
A11P
E15P
A16P
S18P
L19P
F20P
D21P
K22P
T27P
I28P
T29P
T30P
K31P
L33P
T35P
V36P
R38P
S39P
L40P
Q42P
T45P
E46P
A47P
L49P
Q50P
M52P
N54P
E55P
D57P
A58P
T63P
I64P
D65P
F66P
L70P
T71P
M73P
A74P
R75P
K76P
M77P
D79P
T80P
R87P
R91P
G97P
G99P
Y100P
I101P
S102P
A103P
A104P
L106P
R107P
H108P
T111P
L113P
E115P
K116P
L117P
T118P
D119P
V122P
D123P
M125P
R127P
A129P
I131P
G133P
Q136P
N138P
Y139P
Q144P
T147P
A148P